• The antidepressant effect of intermittent theta burst stimulation (iTBS): study protocol for a randomized double-blind sham-controlled trial 

      Ørbo, Marte Christine; Grønli, Ole Kristian; Larsen, Camilla; Vangberg, Torgil Riise; Friborg, Oddgeir; Turi, Zsolt; Mittner, Matthias Bodo; Csifcsak, Gabor; Aslaksen, Per M (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-02)
      Background Intermittent theta burst stimulation (iTBS) when applied over the left dorsolateral prefrontal cortex (DLPFC) has been shown to be equally effective and safe to treat depression compared to traditional repetitive transcranial magnetic stimulation (rTMS) paradigms. This protocol describes a funded single-centre, double-blind, randomized placebo-controlled, clinical trial to investigate ...
    • C-reactive protein levels and depression in older and younger adults - A study of 19,947 individuals. The Tromsø study 

      Bugge, Erlend; Wynn, Rolf; Mollnes, Tom Eirik; Reitan, Solveig Merete Klæbo; Lapid, Maria I.; Grønli, Ole Kristian (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-17)
      In recent years, a connection between depression and inflammation has been established, with a range of immunological changes, both cellular and humoral, presenting during depressive states (Beydoun et al., 2016; Haapakoski et al., 2015; Wium-Andersen et al., 2013). Furthermore, there seems to be a dose-response relationship between depression and inflammation, in the sense that the more severe the ...
    • Changes in cytokines during treatment of elderly, hospitalized psychiatric patients - a naturalistic study 

      Bugge, Erlend; Wynn, Rolf; Mollnes, Tom Eirik; Reitan, Solveig Merete Klæbo; Lapid, Maria; Grønli, Ole Kristian (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-26)
      Immunological abnormalities have been demonstrated in several psychiatric disorders. Predominantly, studies have focused on younger adults, and research on elderly psychiatric in-patients is scant. In this naturalistic study, we investigated changes in cytokine levels during the treatment of diagnostically unselected elderly psychiatric in-patients, and whether these changes could be related to ...
    • The changing alcohol drinking patterns among older adults show that women are closing the gender gap in more frequent drinking: The Tromsø Study, 1994 – 2016 

      Stelander, Line Tegner; Høye, Anne; Bramness, Jørgen Gustav; Selbæk, Geir; Lunde, Linn Heidi; Wynn, Rolf; Grønli, Ole Kristian (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-26)
      Background - As the population of older adults continues to grow, changes in alcohol consumption are important to monitor because an increase may have public health consequences. Rates of alcohol use vary with geographical location. The aim of this study was to examine trends in alcohol consumption among older adults in a geographically defined area in Norway, especially changing sex differences in ...
    • Cytokine profiles and diagnoses in elderly, hospitalised psychiatric patients 

      Bugge, Erlend; Wynn, Rolf; Mollnes, Tom Eirik; Reitan, Solveig Merete Klæbo; Grønli, Ole Kristian (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-27)
      <p><i>Background:</i> There is a paucity of studies on inflammatory markers in elderly psychiatric patients. Hence, our study was undertaken to investigate cytokines as biomarkers in diagnostically unselected elderly patients admitted to a psychiatric hospital. <p><i>Methods:</i> Demographic data, clinical data and blood samples, including 27 cytokines, were collected from 98 patients above 60 ...
    • Depressive symptoms in the general population: The 7th Tromsø Study 

      Grønli, Ole Kristian; Bramness, Jørgen Gustav; Wynn, Rolf; Høye, Anne (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-10)
      Background: The prevalence of depressive symptoms may differ in various age groups. The aim of the study was to investigate the point-prevalence of depressive symptoms in the adult general population and in various age groups. The impact of sex, marital status, education, and social support on depressive symptoms was also explored.<p> <p>Methods: The population ≥40 years in the city of Tromsø, ...
    • The effects of exceeding low-risk drinking thresholds on self-rated health and all-cause mortality in older adults: The Tromsø Study 1994-2020 

      Stelander, Line Tegner; Lorem, Geir F; Høye, Anne; Bramness, Jørgen Gustav; Wynn, Rolf; Grønli, Ole Kristian (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-16)
      Background Based on findings of increasing alcohol consumption in older adults, it is important to clarify the health consequences. Using data from the Tromsø study, we aimed to investigate the relationship between different levels of alcohol consumption in old adulthood and self-rated health trajectories and all-cause mortality.<p> <p>Methods This is an epidemiological study utilizing repeated ...
    • Fear of diseases among people over 50 years of age : a survey 

      Bystad, Martin Kragnes; Grønli, Ole Kristian; Lilleeggen, Camilla; Aslaksen, Per M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-12-11)
      The aim of this study was to investigate the association between well-known diseases and fear of them in individuals over 50 years of age. Information on the fear of diseases can be relevant for both public health information purposes and clinical setting diagnostics. However, very few studies have investigated the fear of diseases in individuals over the age of 50. We used an electronic survey ...
    • A four-month home-based tDCS study on patients with Alzheimer’s disease 

      Grønli, Ole Kristian; Rasmussen, Ingrid Daae; Aslaksen, Per M; Bystad, Martin Kragnes (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-19)
      In the present open-label study, our first aim was to study the tolerability and feasibility of long-term treatment with transcranial direct current stimulation (tDCS) and the second aim was to measure whether the treatment led to cognitive improvement. Participants with AD used a tDCS home-treatment kit inducing a low current (2 mA) via two scalp electrodes 30 minutes daily for 4 months. A total ...
    • High-Definition Transcranial Direct Current Stimulation Improves Delayed Memory in Alzheimer’s Disease Patients: A Pilot Study Using Computational Modeling to Optimize Electrode Position 

      Rasmussen, Ingrid Daae; Boayue, Nya Mehnwolo; Mittner, Matthias; Bystad, Martin Kragnes; Grønli, Ole Kristian; Vangberg, Torgil Riise; Csifcsak, Gabor; Aslaksen, Per M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-14)
      Background: The optimal stimulation parameters when using transcranial direct current stimulation (tDCS) to improve memory performance in patients with Alzheimer’s disease (AD) are lacking. In healthy individuals, inter-individual differences in brain anatomy significantly influence current distribution during tDCS, an effect that might be aggravated by variations in cortical atrophy in AD ...
    • Risk of malnutrition and zinc deficiency in community-living elderly men and women: the Tromsø Study 

      Kvamme, Jan-Magnus; Grønli, Ole Kristian; Jacobsen, Bjarne Koster; Florholmen, Jon (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-11-06)
    • Risk of malnutrition is associated with mental health symptoms in community living elderly men and women: The Tromsø Study 

      Kvamme, Jan-Magnus; Grønli, Ole Kristian; Florholmen, Jon; Jacobsen, Bjarne Koster (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Little research has been done on the relationship between malnutrition and mental health in community living elderly individuals. In the present study, we aimed to assess the associations between mental health (particularly anxiety and depression) and both the risk of malnutrition and body mass index (BMI, kg/m2) in a large sample of elderly men and women from Tromsø, Norway. In a cross-sectional ...
    • Sex differences in at-risk drinking and associated factors–a cross-sectional study of 8,616 community-dwelling adults 60 years and older: the Tromsø study, 2015-16 

      Stelander, Line Tegner; Grønli, Ole Kristian; Høye, Anne; Bramness, Jørgen Gustav; Wynn, Rolf (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-01)
      Background: Alcohol consumption among older adults is on the rise, which may be an increasing public health concern. The proportion of older adults who drink above defined low-risk drinking limits, associated characteristics and the sex distribution of at-risk drinking vary across countries. The aims of this study were to (i) estimate the prevalence of at-risk drinking among older adults in Norway, ...
    • A study of some biological factors of importance to geriatric psychiatry. 

      Grønli, Ole Kristian (Doctoral thesis; Doktorgradsavhandling, 2014-09-12)
      Det er lite kunnskap om vitamin D og sink mangel hos eldre med psykiske lidelser. I en case-control studie fant vi signifikant lavere serum nivå av 25(OH)D i en eldre (>64 år) pasient gruppe sammenlignet med en eldre kontroll gruppe (40.5 nmol/L vs. 65.9 nmol/L). Prevalens av vitamin D mangel (def: 25(OH) D<50 nmol/L) var 71.6% i pasient gruppen mot 20.0% i kontroll gruppen. Det var ikke forskjell ...
    • Transcranial direct current stimulation as a memory enhancer in patients with Alzheimer’s disease: a randomized, placebo-controlled trial 

      Bystad, Martin Kragnes; Grønli, Ole Kristian; Rasmussen, Ingrid Daae; Gundersen, Nina; Nordvang, Lene; Wang-Iversen, Henrik A.S.; Aslaksen, Per M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-03-23)
      <p><i>Background:</i> The purpose of this study was to assess the efficacy of transcranial direct current stimulation (tDCS) on verbal memory function in patients with Alzheimer’s disease. <p><i>Methods:</i> We conducted a randomized, placebo-controlled clinical trial in which tDCS was applied in six 30-minute sessions for 10 days. tDCS was delivered to the left temporal cortex with 2-mA intensity. ...
    • Vitamin D deficiency is common in psychogeriatric patients, independent of diagnosis 

      Grønli, Ole Kristian; Kvamme, Jan-Magnus; Jorde, Rolf; Wynn, Rolf (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-05-08)
      Background:Previous studies have found an association between psychiatric disorders and vitamin D deficiency, but most studies have focused on depression. This study aimed to establish the prevalence of vitamin D deficiency in elderly patients with a wider range of psychiatric diagnoses. Method: The study included elderly patients (>64 years) referred to a psychiatric hospital in Northern Norway ...
    • Zinc deficiency is common in several psychiatric disorders 

      Grønli, Ole Kristian; Kvamme, Jan-Magnus; Friborg, Oddgeir; Wynn, Rolf (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Background: Mounting evidence suggests a link between low zinc levels and depression. There is, however, little knowledge about zinc levels in older persons with other psychiatric diagnoses. Therefore, we explore the zinc status of elderly patients suffering from a wide range of psychiatric disorders. Methods: Clinical data and blood samples for zinc analyzes were collected from 100 psychogeriatric ...